The "Angels," three investigative agents (Barrymore, Diaz and Liu) who work for the Charles Townsend Detective Agency, return for another high-octane series of adventures as they investigate the theft of a database of witness protection profiles, after five of the people on the list are murdered. They're aided by a new Bosley (Mac) in an adventure which pits them against a "fallen angel" (Moore), their old nemesis the Thin Man (Glover) and others.